VisionUnder the world's most advanced research and development environment in the regenerative medicine area in Japan, we are aiming to achieve a medical innovation through our unique and cutting-edge cell therapy technology in the liver disease field, where all the patients in the world may be able to undergo ultimate and safer treatment to realize a healty longevity society.
|Regenerative Medicine||Liver disease treatment with liver cell sheets
We are developing the new regenerative medicine for liver disease, using liver cell sheets which are differentiated with a low molecular weight compounds from mesenchymal stem cells (MSCs).
|Drug Discovery||Liver disease treatment with low-molecular-weight compounds
In the middle term, we are also developing a new liver desease treatment with novel low-molecular-weight compounds for liver regeneration.
Reference1. Identification of the small molecule compound which induces hepatic differentiation of human mesenchymal stem cells. Regenerative Therapy 2015, 2:32-41.
2. Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice. Sci Rep. 2015, 5: 16169.
Suppression and regeneration promoting effect of low molecular weight compound on cancer and fibrosis
PCT/JP2016/077475, Taiwan I636983
Inhibitory effect of low molecular weight compound on cancer and fibrosis
PCT/JP2015/059257, US2018/0,028,536, EP3150207
Synthesis and analysis of compounds capable of including differentiation of human mesenchymal stem cells into hepatocytes
PCT/JP2012/059021, US9,555,061, EP2698365